Connect with us

Hi, what are you looking for?


Lower prostate cancer screening rates linked with more advanced cancers


A DECLINE in prostate cancer screening has been linked to subsequent increases in advanced cancers, according to data from the US Department of Veterans Affairs (VA), findings that may spur revisiting current US testing guidelines.  

A new study, involving more than 5 million men over age 40 at 128 VA facilities across the country between 2005 and 2019, found that when screening was encouraged, later diagnoses of incurable advanced malignancies were less likely.  

“Screening rates were significant predictors of metastatic cancer rates,” study leader Dr. Brent Rose of the University of California, San Diego said at a news conference on Monday at the annual meeting of the American Society for Radiation Oncology (ASTRO) in San Antonio, Texas. Metastatic cancers are those that have advanced and spread to other parts of the body.  

The benefits of screening for prostate cancer have been controversial. In 2012, the US Preventive Services Task Force (USPSTF) advised against it, maintaining that because the disease usually progresses very slowly, the risks of screening outweigh the potential benefit. There was concern that suspicion of prostate cancer based on a common blood test could lead to painful, potentially risky biopsies that may not have been necessary.  

In 2018, based on new evidence, the panel modified its recommendation to limit prostate cancer screening to men ages 55 to 69, and then only if they “express a preference for screening after being informed of and understanding the benefits and risks.”  

Overall at the VA facilities, rates of screening with blood tests for prostate-specific antigen levels dropped from 47.2% in 2005 to 37.0% in 2019, the researchers reported.  

During that period, metastatic prostate cancer rates rose from 5.2 per 100,000 men to 7.9 per 100,000, with the rise driven by increases in the 55–69 and over-70 age groups, the researchers said.  

At individual facilities, higher rates of screening were linked with lower rates of subsequent diagnoses of advanced cancers. But for every 10% decrease in screening, there was a corresponding 10% increase in metastatic prostate cancer incidence five years later, the researchers said.  

Observational studies like this one cannot prove cause and effect, and earlier randomized trials comparing screening to no screening have yielded conflicting results, further complicating the issue. A large European trial found a significant benefit, but a North American trial did not.  

In the North American trial, however, many of the men assigned to the no-screening group “surreptitiously” were screened privately by their personal physicians, which likely biased the outcomes, ASTRO president-elect Dr. Jeff Michalski of Washington University School of Medicine in St. Louis said at the news conference.  

Dr. Rose noted that while the USPSTF advice to limit prostate cancer screening has resulted in lower rates of prostate cancer diagnoses, rates of metastatic prostate cancer have increased “more dramatically.”  

“We hope this data will give the USPSTF a chance to re-evaluate their recommendations,” Dr. Michalski said.  

A spokesperson for the USPSTF said an update to its prostate cancer screening recommendation is not currently underway. — Reuters 

Your information is secure and your privacy is protected. By opting in you agree to receive emails from us. Remember that you can opt-out any time, we hate spam too!



REUTERS/ELOISA LOPEZ LOCAL SHARES are expected to move within a limited range this week as investors await the release of November consumer price index...


CRECENCIO I. CRUZ THE PESO may continue to strengthen against the dollar this week ahead of the release of November inflation data that could...


JULIAN ALVAREZ OF ARGENTINA — REUTERS AL RAYYAN, Qatar — Lionel Messi scored his first goal in a World Cup knockout round in his...


BETTINA Binaohan, Charmine Torres and Lee Sario backstopped Tchuido for the Lady Archers, who gained a separation at 61-52 midway through the fourth. —...


MARIE Antoinette San Diego — FIDE MARIE Antoinette San Diego has been dreaming of becoming national champion since childhood. The search for the 23-year-old...


LONDON — Britain’s Tyson Fury roared out a challenge to rival heavyweight world champion Oleksandr Usyk of Ukraine after retaining his WBC title with...

You May Also Like


BW FILE PHOTO GROSS BORROWINGS by the National Government reached P2.6 trillion as of end-September as it continued to raise funds to respond to...


REUTERS By Luz Wendy T. Noble, Reporter The country’s foreign exchange buffers slightly increased as of end-October as the value of the central bank’s...


KARASOLAR.COM TENA, Ecuador — Ecuador’s rainforest Achuar people say their ancestors long dreamed of a “fire canoe” or “electric fish” that would let them...


COVID-19 has had a significant impact on the mental health of Filipinos across different groups all over the archipelago. From frontline workers, parents balancing...

Disclaimer: Respect, its managers, its employees, and assigns (collectively "The Company") do not make any guarantee or warranty about what is advertised above. Information provided by this website is for research purposes only and should not be considered as personalized financial advice. The Company is not affiliated with, nor does it receive compensation from, any specific security. The Company is not registered or licensed by any governing body in any jurisdiction to give investing advice or provide investment recommendation. Any investments recommended here should be taken into consideration only after consulting with your investment advisor and after reviewing the prospectus or financial statements of the company.

Copyright © 2022 Respect Investment. All Rights Reserved.